FOR 1368

Hemodynamic Mechanisms of Acute Kidney Injury

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Publications

Publications 2017:

 

Himmerkus N, Plain A, Marques RD, Sonntag SR, Paliege A, Leipziger J, Bleich M: AVP dynamically increases paracellular Na+ permeability and transcellular NaCl transport in the medullary thick ascending limb of Henle's loop. Pflugers Arch. 2017, 469: 149-158. (doi: 10.1007/s00424-016-1915-5). Review.

 

Dittmayer C, Völcker E, Wacker I, Schröder R, Bachmann S: Scanning electron microscopy of thin sections: A technique to overcome limitations in kidney ultrastructural research. Ultrastruct Pathol. 2017, 41: 119-120. (doi: 10.1080/01913123.2016.1272165).

 

Blankenstein KI, Borschewski A, Labes R, Paliege A, Boldt C, McCormick JA, Ellison DH, Bader M, Bachmann S, Mutig K: Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms. Am J Physiol Renal Physiol. 2017, 312: F489-F501. (doi: 10.1152/ajprenal.00575.2016).

 

Westhoff JH, Seibert FS, Waldherr S, Bauer F, Tönshoff B, Fichtner A, Westhoff TH: Urinary calprotectin, kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin for the prediction of adverse outcome in pediatric acute kidney injury. Eur J Pediatr. 2017, 176: 745-755. (doi: 10.1007/s00431-017-2907-y).

 

Werth M*, Schmidt-Ott KM*, Leete T, Qiu A, Hinze C, Viltard M, Paragas N, Shawber CJ, Yu W, Lee P, Chen X, Sarkar A, Mu W, Rittenberg A, Lin CS, Kitajewski J, Al-Awqati Q, Barasch J. Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts. eLife 2017;6:e24265. *Co-first
https://elifesciences.org/articles/24265
Kommentar:
Aguilar A. Tfcp2l1 drives Notch signalling and epithelial diversity in the collecting duct. Nature Reviews Nephrology (2017). https://www.nature.com/nrneph/journal/vaop/ncurrent/full/nrneph.2017.93.html 

 

Persson PB : Renoprotection. Acta Physiol. (Oxf). 2017, 219: 540-541. (doi: 10.1111/apha.12683). 

 

Seibert FS, Westhoff TH: Renoprotection in acute kidney injury – quoi de neuf? Acta Physiol. (Oxf). 2017, 219: 542-543. (doi: 10.1111/apha.12715).

 

Schrezenmeier EV, Barasch J, Budde K, Westhoff T, Schmidt-Ott KM: Biomarkers in acute kidney injury – pathophysiological basis and clinical performance. Acta Physiol. (Oxf). 2017, 219: 554-572. (doi: 10.1111/apha.12764). Review.

 

Markó L, Mannaa M, Haschler TN, Krämer S, Gollasch M: Renoprotection: focus on TRPV1, TRPV4, TRPC6 and TRPM2. Acta Physiologica (Oxf). 2017, 219: 589-612. (DOI: 10.1111/apha.12828)

 

Kork F, Balzer F, Krannich A, Bernardi MH, Eltzschig HK, Jankowski J, Spies C: Back-calculating baseline creatinine overestimates prevalence of acute kidney injury with poor sensitivity. Acta Physiol. (Oxf). 2017, 219: 613-624. (doi: 10.1111/apha.12763).

 

Fähling M, Mathia S, Scheidl J, Abramovitch R, Milman Z, Paliege A, Peters H, Persson PB, Heyman SN, Rosenberger C: Cyclosporin a induces renal episodic hypoxia. Acta Physiol (Oxf). 2017, 219: 625-639. (doi: 10.1111/apha.12811). 

 

Seibert FS, Rosenberger C, Mathia S, Arndt R, Arns W, Huppertz A, Pagonas N, Bauer F, Zidek W, Westhoff TH: Urinary calprotectin differentiates between prerenal and intrinsic acute renal allograft failure. Transplantation 2017, 101: 387-394. (doi: 10.1097/TP.0000000000001124).

 

  

Publications 2016:

 

Boldt C, Röschel T, Himmerkus N, Plain A, Bleich M, Labes R, Blum M, Krause H, Magheli A, Giesecke T, Mutig K, Rothe M, Weldon SM, Dragun D, Schunck WH, Bachmann S, Paliege A: Vasopressin lowers renal epoxyeicosatrienoic acid levels by activating soluble epoxide hydrolase. Am J Physiol Renal Physiol, 311(6): F1198-F1210, 2016. (doi: 10.1152/ajprenal.00062.2016)

 

Niendorf T, Paul K, Oezerdem C, Graessl A, Klix S, Huelnhagen T, Hezel F, Rieger J, Waiczies H, Frahm J, Nagel A, Oberacker E, Winter L. W(h)ither Human Cardiac and Body Magnetic Resonance at Ultrahigh Fields? Technical Advances, Practical Considerations, Applications, and Clinical Opportunities NMR Biomed. 2016 Sep;29(9):1173-97. doi: 10.1002/nbm.3268. Review.

 

Westhoff JH, Fichtner A, Waldherr S, Pagonas N, Seibert FS, Babel N, Tönshoff B, Bauer F, Westhoff TH: Urinary biomarkers for the differentiation of prerenal and intrinsic pediatric acute kidney injury. Pediatr Nephrol. 31(12):2353-2363, 2016. (doi: 10.1007/s00467-016-3418-1)

 

Markó L, Szijártó IA, Filipovic MR, Kaßmann M, Balogh A, Park JK, Przybyl L, N'diaye G, Krämer S, Anders J, Ishii I, Müller DN, Gollasch M: Role of cystathionine gamma-lyase in immediate renal impairment and inflammatory response in acute ischemic kidney injury. Sci Rep. 2016 6:27517 (doi: 10.1038/srep27517).

 

Cantow K, Pohlmann A, Flemming B, Ferrara F, Waiczies S, Grosenick D, Niendorf T, Seeliger E: Acute effects of ferumoxytol on regulation of renal hemodynamics and oxygenation. Sci Rep. 2016 Jul 20;6:29965. (doi: 10.1038/srep29965).

    
Ebbing J, Seibert FS, Pagonas N, Bauer F, Miller K, Kempkensteffen C, Günzel K, Bachmann A, Seifert HH, Rentsch CA, Ardelt P, Wetterauer C, Amico P, Babel N, Westhoff TH: Dynamics of Urinary Calprotectin after Renal Ischaemia. PLoS One 11(1), e0146395, 2016 (doi: 10.1371/journal.pone.0146395)

 

Pohlmann A, Arakelyan K, Seeliger E, Niendorf T. Magnetic Resonance Imaging (MRI) Analysis of Ischemia/Reperfusion in Experimental Acute Renal Injury. Methods Mol Biol 1397: 113-127, 2016 (doi: 10.1007/978-1-4939-3353-2_10)

 

Cantow K, Arakelyan K, Seeliger E, Niendorf T, Pohlmann A. Assessment of Renal Hemodynamics and Oxygenation by Simultaneous Magnetic Resonance Imaging (MRI) and Quantitative Invasive Physiological Measurements. Methods Mol Biol 1397: 129-154, 2016 (doi: 10.1007/978-1-4939-3353-2_11)

 

Marko L*, Vigolo E*, Hinze C, Park JK, Roel G, Balogh A, Choi M, Wuebken A, Cording J, Blasig IE, Luft FC, Scheidereit C, Schmidt-Ott KM**, Schmidt-Ullrich R**, Muller DN**. Tubular Epithelial NF-kB Activity Regulates Ischemic AKI. J Am Soc Nephrol 9: 2658-2669, 2016. Published online adhead of print. *Co-first, **Equally contributing principle investigators. Comments can be read here:
English:
https://www.mdc-berlin.de/45556228/en/news/2016/20160128-Ischemic_renal_failure_and_organ_damage_a_new_mouse_model_holds_the_key

Deutsch:
https://www.mdc-berlin.de/45556176/de/news/2016/20160128-Ischaemisches_Nierenversagen_zelltypspezifisches_Mausmodell_erklaert_Ursache_fuer_Organschaedigungen

Dies wurde u. a. auch von Medizin-Aspekte und Eurekalert aufgegriffen:
http://medizin-aspekte.de/nierenversagen-forscher-finden-ursache-fuer-organschaedigungen

http://www.eurekalert.org/pub_releases/2016-01/mdcf-irf012816.php

 

  

Publications 2015:

 

Neymeyer H, Labes R, Reverte V, Saez F, Stroh T, Dathe C, Hohberger S, Zeisberg M, Müller GA, Salazar J, Bachmann S, Paliege A: Activation of annexin A1 signalling in renal fibroblasts exerts antifibrotic effects. Acta Physiol. (Oxf) 215: 144–158, 2015 (doi: 10.1111/apha.12586)

 

Niendorf T, Pohlmann A, Reimann HM, Waiczies H, Peper E, Huelnhagen T, Seeliger E, Schreiber A, Kettritz R, Strobel K, Ku MC, Waiczies S. Advancing Cardiovascular, Neurovascular, and Renal Magnetic Resonance Imaging in Small Rodents Using Cryogenic Radiofrequency Coil Technology. Front Pharmacol 6: 255, 2015. (doi: 10.3389/fphar.2015.00255)

 

Walentin K, Hinze C, Werth M, Haase N, Varma S, Morell R, Aue A, Pötschke E, Warburton D, Qiu A, Barasch J, Purfürst B, Dieterich C, Popova E, Bader M, Dechend R, Staff AC, Yurtdas ZY, Kilic E, Schmidt-Ott KM. A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development 142: 1125-1136, 2015 (doi: 10.1242/dev.113829)


Aue A, Hinze C, Walentin K, Ruffert J, Yurtdas ZY, Werth M, Chen W, Rabien A, Kilic E, Schulzke JD, Schumann M, Schmidt-Ott KM. A grainyhead-like 2/ovo-like 2 pathway regulates renal epithelial barrier function and lumen expansion. J Am Soc Nephrol 26: 2704-2715, 2015 (doi: 10.1681/ASN.2014080759)

 

Salem S, Jankowski V, Asare Y, Liehn EA, Welker P, Raya-Bermudez A, Pineda-Martos C, Rodriguez M, Muñoz-Castañeda JR, Bruck H, Marx N, Machado FB, Staudt M, Heinze G, Zidek W, Jankowski J: Identification of the “vasoconstriction inhibiting factor” (VIF), a potent endogenous cofactor of angiotensin II acting on the AT2 receptor. Circulation 131: 1426-1434, 2015 (doi:10.1161/CIRCULATIONAHA.114.013168)

 

Staudacher JJ, Naarmann-de Vries I, Ujvari SJ, Klinger B, Kasim M, Benko E, Ostareck-Lederer A, Ostareck DH, Bondke Persson A, Lorenzen S, Meier JC, Blüthgen N, Persson PB, Henrion-Caude A, Mrowka R, Fähling M: Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum. Nucleic Acids Res 43: 3219-3236, 2015 (doi: 10.1093/nar/gkv167)

 

Kaufmann J, Martinka P, Moede O, Sendeski M, Steege A, Fähling M, Hultström M, Gaestel M, Moraes-Silva IC, Nikitina T, Liu ZZ, Zavaritskaya O, Patzak A: Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries. Acta Physiol (Oxf) 213: 920-932, 2015 (doi: 10.1111/apha.12457)

Grosenick D, Cantow K, Arakelyan K, Wabnitz H, Flemming B, Skalweit A, Ladwig M, Macdonald R, Niendorf T, Seeliger E: Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach. Biomedical Optics Express 6: 309-323, 2015

Chen L, Kaßmann M, Sendeski M, Tsvetkov D, Marko L, Michalick L, Riehle M, Liedtke WB, Kuebler WM, Harteneck C, Tepel M, Patzak A, Gollasch M: Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature. Acta Physiol (Oxf) 213: 481-91, 2015 (doi: 10.1111/apha.12470)

Patzak A, Carlström M, Sendeski MM, Lai EY, Liu ZZ, Sällström J, Flöge J, Heintz B, Jankowski J, Jankowski V: Diadenosine pentaphosphate modulates glomerular arteriolar tone and glomerular filtration rate. Acta Physiol (Oxf) 213: 285-93, 2015 (doi: 10.1111/apha.12425)

Niendorf T, Pohlmann A, Arakelyan K, Flemming B, Cantow K, Hentschel J, Grosenick D, Ladwig M, Reimann H, Klix S, Waiczies S, Seeliger E: How bold is bold oxygenation level-dependent (BOLD) magnetic resonance imaging of the kidney? Opportunities, challenges and future directions. Acta Physiol (Oxf) 213: 19-38, 2015 (doi: 10.1111/apha.12393)

 

  

Publications 2014:

 

Kasim M, Benko E, Winkelmann A, Mrowka R, Staudacher JJ, Persson PB, Scholz H, Meier JC, Fähling M: Shutdown of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia. J Biol Chem 289(39): 26973-88, 2014

Förstera B, a Dzaye OD, Winkelmann A, Semtner M, Benedetti B, Markovic DS, Synowitz M, Wend P, Fähling M, Junier MP, Glass R, Kettenmann H, Meier JC: Intracellular glycine receptor function facilitates glioma formation in vivo. J Cell Sci 127(Pt 17): 3687-98, 2014

 

Speer T, Owala FO, Holy EW, Zewinger S, Frenzel FL, Stähli BE, Razavi M, Triem S, Cvija H, Rohrer L, Seiler S, Heine GH, Jankowski V, Jankowski J, Camici GG, Akhmedov A, Fliser D, Lüscher TF, Tanner FC: Carbamylated low-density lipoprotein induces endothelial dysfunction. Eur Heart J 35: 3021-32, 2014

Schulz A, Jankowski V, Zidek W, Jankowski J: Highly sensitive, selective and rapid LC-MS method for simultaneous quantification of diadenosine polyphosphates in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 961: 91-6, 2014

Schulz A, Jankowski J, Zidek W, Jankowski V: Absolute quantification of endogenous angiotensin II levels in human plasma using ESI-LC-MS/MS. Clin Proteomics 11: 37, 2014


Schmidt-Ott KM: The Ebf1 knockout mouse and glomerular maturation. Kidney Int 85:1014-6, 2014

Ebbing J, Mathia S, Seibert F, Pagonas N, Bauer F, Erber B, Günzel K, Kilic E, Kempkensteffen C, Miller K, Bachmann A, Rosenberger C, Zidek W, Westhoff TH: Urinary calprotectin: A new diagnostic marker in urothelial carcinoma of the bladder. World J Urol 32(6), 1485-92, 2014 (doi: 10.1007/s00345-013-1227-8)                                            

 

Tepel M, Borst C, Bistrup C, Marcussen N, Pagonas N, Seibert FS, Arndt R, Zidek W, Westhoff TH: Urinary calprotectin and posttransplant renal allograft injury. PLoS One 9(11): e113006, 2014 (doi: 10.1371/journal.pone.0113006)

Kloepper JE, Ernst N, Krieger K, Bodó E, Bíró T, Haslam IS, Schmidt-Ullrich R, Paus R: NF-?B activity is required for anagen maintenance in human hair follicles in vitro. J Invest Dermatol 134: 2036-8, 2014

Fischer R, Konkel A, Mehling H, Blossey K, Gapelyuk A, Wessel N, von Schacky C, Dechend R, Muller DN, Rothe M, Luft FC, Weylandt K, Schunck WH: Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway. J Lipid Res 55: 1150-1164, 2014 

Keller J, Ellieva A, Ma DK, Ju J, Nehk E, Konkel A, Falck JR, Schunck WH, Menzel R: CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation. Biochem J 464: 61-71, 2014

 

Liu ZZ, Schmerbach K, Lu Y, Perlewitz A, Nikitina T, Cantow K, Seeliger E, Persson PB, Patzak A, Liu R, Sendeski MM: Iodinated contrast media cause direct tubular cell damage, leading to oxidative stress, low nitric oxide, and impairment of tubulo-glomerular feedback. Am J Physiol, Renal Physiol 306: F864-F872, 2014

Seeliger E, Cantow K, Arakelyan K, Ladwig M, Persson PB, Flemming B: Low-dose nitrite alleviates early effects of an X-ray contrast medium on renal hemodynamics and oxygenation in rats. Investigative Radiology 49: 70-77, 2014

Potthoff SA, Fähling M, Clasen T, Mende S, Ishak B, Suvorava T, Stamer S, Thieme M, Sivritas SH, Kojda G, Patzak A, Rump LC, Stegbauer J: Angiotensin-(1-7) modulates renal vascular resistance through inhibition of p38 mitogen-activated protein kinase in apolipoprotein E-deficient mice. Hypertension 63: 265-272, 2014

Brinkmann O, Schmerbach K, Tietge U, Dietrich T, Guski H, Linz D, Kühn H, Patzak A, Wilfert K: Changes in arterial function in a mouse model of human familial hypercholesterolemia. Acta Physiologica 211: 61-72, 2014

Pohlmann A, Arakelyan K, Hentschel J, Cantow K, Flemming B, Ladwig M, Waiczies S, Seeliger E, Niendorf T: Detailing the relation between renal T2* and renal tissue pO2 using an integrated approach of parametric magnetic resonance imaging and invasive physiological measurements. Investigative Radiology 49: 547-560, 2014

Muoio V, Persson PB, Sendeski MM: The neurovascular unit – concept review. Acta Physiologica 210: 790-798, 2014

Seeliger E, Lenhard DC, Persson PB: Contrast media viscosity versus osmolality in kidney injury: lesson from animal studies. Hindawi Publishing Corporation BioMed Research Intern. ID 358136 2014 (REV)

Gille C, Fähling M, Weyand B, Wieland T, Gille A: Alignment-Annotator web server: rendering and annotating sequence alignments. Nucleic Acids Research 12: Web server issue W3-W6, 2014 (doi: 10.1093/nar/gku400)

Koeners MP, Vink EE, Kuijper A, Gadellaa N, Rosenberger C, Mathia S, van den Meiracker AH, Garrelds IM, Blankestijn PJ, Joles JA: Stabilization of hypoxia inducible factor-1α ameliorates acute renal neurogenic hypertension. J Hypertension 32: 587-597, 2014



Publications 2013:

Persson PB: Mechanisms of acute kidney injury. Acta Physiologica 207: 430-431, 2013

Kaßmann M, Harteneck C, Zhu Z, Nürnberg B, Tepel M, Gollasch M: Transient receptor potential vanilloid 1 (TRPV1), TRPV4, and the kidney. Acta Physiologica 207: 546-564, 2013

Sendeski MM, Liu ZZ, Perlewitz A, Busch JF, Ikromov O, Weikert S, Persson PB, Patzak A: Functional characterization of isolated, perfused outermedullary descending human vasa recta. Acta Physiologica 208: 50-56, 2013

Arakelyan K, Cantow K, Hentschel J, Flemming B, Pohlmann A, Ladwig M, Niendorf T, Seeliger E: Early effects of an x-ray contrast medium on renal T2*/T2MRI as compared to short-term hyperoxia, hypoxia and aortic occlusion in rats. Acta Physiologica 208: 202-213, 2013

Kusch A, Hoff U, Bubalo G, Zhu Y, Fechner M, Schmidt-Ullrich R, Marko L, Müller DN, Schmidt-Ott KM, Gürgen D, Blum M, Schunck W-H, Dragun D: Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury. Acta Physiologica 208: 25-40, 2013

E. Singer E, L. Markó L, N. Paragas N, J. Barasch L, D. Dragun D, D. N. Müller DN, K. Budde K and K. M. Schmidt-Ott KM: Neutrophil gelatinase-associated lipocalin: pathophysiology and clinical applications. Acta Physiologica 207: 663-672, 2013

Seibert FS, Pagonas N, Arndt R, Heller F, Dragun D, Persson P, Schmidt-Ott K, Zidek W, Westhoff TH: Calprotectin and neutrophil gelatinase-associated lipocalin in the differentiation of pre-renal and intrinsic acute kidney injury. Acta Physiologica 207: 700-708, 2013

Fähling M, Mathia S, Paliege A, Koesters R, Mrowka R, Peters H, Persson PB, Neumayer HH, Bachmann S, Rosenberger C: Tubular von Hippel-Lindau knockout protects against rhabdomyolysis-induced AKI. Journal of the American Society of Nephrology 24: 1806-1819, 2013

Mathia S, Paliege A, Koesters R, Peters H, Neumayer H-H, Bachmann S, Rosenberger C: Action of hypoxia-inducible factor in liver and kidney from mice with Pax8-rtTA-based deletion of von Hippel-Lindau protein. Acta Physiologica 207: 565-576, 2013

Dietrich A, Mathia S, Kaminski H, Mutig K, Rosenberger C, Mrowka R, Bachmann, Paliege A: Chronic activation of vasopressin V2 receptor signalling lowers renal medullary oxygen levels in rats. Acta Physiologica 207: 721-731, 2013

Milman Z, Heyman SN, Corchia N, Edrei Y, Axelrod JH, Rosenberger C, Tsarfati G, Arbamovitch R: Hemodynamic response magnetic resonance imaging: application for renal hemodynamic characterization. Nephrol Dial Transplant 28(5): 1150-1156, 2013

Nechemia-Arbely Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, geva C, Shriki A, Klaus S, Rosen S, Rose-John S, Galun E, Axelrod JH, Heyman SN: In vivo evidence suggesting reciprocal renal HIF-1 up-regulation and STAT3 activation in response to hypoxic and non-hypoxic stimuli. Clin Exp Pharmacol Physiol 40(4): 262-272, 2013

Nagaku M, Rosenberger C, Heyman SN, Eckardt KU: HIF regulation in kidney disease. Clin Exp Pharmacol Physiol 40(2): 148-157, 2013

Grosenick D, Steinkellner O, Wabnitz H, Macdonald R, Niendorf T, Cantow K, Flemming B, Seeliger E: Near-infrared spectroscopy of renal tissue in vivo. Proceeding of SPIE 8578: 85781P-1, 2013

Pohlmann A, Cantow K, Hentschel J, Arakelyan K, Ladwig M, Flemming B, Hoff U, Persson PB, Seeliger E, Niendorf T: Linking non-invasive parametric MRI with invasive physiological measurements (MR-PHYSIOL): towards a hybrid and integrated approach for investigation of acute kidney injury in rats. Acta Physiologica 207: 673-689, 2013

Pohlmann A, Hentschel J, Fechner M, Hoff U, Bubalo G, Arakelyan K, Cantow K, Seeliger E, Flemming B, Waiczies H, Waiczies S, Schunck WH, Dragun D, Niendorf T: High temporal resolution parametric MRI monitoring of the initial ischemia/reperfusion phase in experimental acute kidney injury. PLoS One 8(2):e57411, 2013


Publications 2012:

Gollasch M: Vasodilator signals from perivascular adipose tissue. Br J Pharmacol. 165(3): 633-642, 2012 (Review)

Thilo F, Liu Y, Loddenkemper C, Schuelein R, Schmidt A, Yan Z, Zhu Z, Zakrzewicz A, Gollasch M, Tepel M: VEGF regulates TRPC6 channels in podocytes. Nephrol Dial Transplant. 27 (3): 921-929, 2012

Thilo F, Li Y, Krueger K, Forste N, Wittstock A, Scholze A, Tepel M: Do cysteine residues regulate transient receptor potential canonical type 6 channel protein expression? Antioxid Redox Signal 16(5): 452-457, 2012

Thilo F, Vorderwulbecke BJ, Marki A, Krueger K, Liu Y, Baumunk D, Zakrzewicz A, Tepel M: Pulsatile atheroprone shear stress affects the expresson of transient receptor potential channels in human endothelial cells. Hypertension 59(6): 1232-1240, 2012

Lukitsch I, Kehr J, Chaykovska L, Wallukat G, Nieminen-Kelha M, Batuman V, Dragun D, Gollasch M: Renal ischemia and transplantation predispose to vascular constriction mediated by angiotensin II type 1 receptor-activating antibodies. Transplantation 94(1): 8-13, 2012

Liu Y, Echtemeyer F, Thilo F, Theilmeier G, Schmidt A, Schulein R, Jensen BL, Loddenkemper C, Jankowski V, Marcussen N, Gollasch M, Arendshorst WJ, Tepel M: The proteoglycan syndecan 4 regulates transient receptor potential canonical 6 channels via RhoA/Rho-associated protein kinase signaling. Arterioscler Thromb Vasc Biol 32(2): 378-385, 2012

Perlewitz A, Persson AE, Patzak A: The juxtaglomerular apparatus. Acta Physiol. 205: 6-8, 2012

Schmerbach K, Patzak A: The renin-angiotensin system – a functional ‘jack-of-all-trades’. Acta Physiol. 205: 453-455, 2012

Viegas VU, Liu ZZ, Nikitina T, Perlewitz A, Zavaritskaya O, Schlichting J, Persson PB, Regitz-Zagrosek V, Patzak A, Sendeski MM: Angiotensin II type 2 receptor mediates sex differences in mice renal interlobar arteries response to angiotensin II. J Hypertens. 30: 1791-1798, 2012

Liu ZZ, Viegas VU, Perlewitz A, Lai EY, Persson PB, Patzak A, Sendeski MM: Iodinated contrast media differentially affect afferent and efferent arteriolar tone and reactivity in mice: A possible explanation for reduced glomerular filtration rate. Radiol. 265: 762-771, 2012

Fähling M, Bondke Persson A, Klinger B, Benko E, Steege A, Kasim M, Patzak A, Persson PB, Wolf G, Blüthgen N, Mrowka R: Multilevel regulation of HIF-1 signaling by TTP. Mol Biol Cell. 23: 4129-4141, 2012

Sendeski MM, Bondke Persson A, Liu ZZ, Busch JF, Weikert S, Persson PB, Hippenstiel S, Patzak A: Iodinated contrast media cause endothelial damage leading to vasoconstriction of human and rat vasa recta. Am J Physiol Renal Physiol. 303: F1592-F1598, 2012

Seeliger E, Sendeski M, Rihal CS, Persson PB: Contrast-induced kidney injury: mechanisms, risk factors, and prevention. Europ Heart J. 33: 2007-2015, 2012 (Review)

Seeliger E, Ladwig M, Sargsyan L, Cantow K, Persson PB, Flemming B: Proof of Principle: Hydration by Low-osmolar Mannitol-Glucose Solution Alleviates Undesirable Renal Effects of an Iso-osmolar Contrast Medium in Rats. Invest Radiol. 47: 240-246, 2012

Haase M, Bellomo R, Story D, Letis A, Klemz K, Matalanis G, Seevanayagam S, Dragun D, Seeliger E, Mertens PR, Haase-Fielitz A: Effect of mean arterial pressure, haemoglobin and blood transfusion during cardiopulmonary bypass on post-operative acute kidney injury. Nephrol Dial Transplantation 27(1): 153-160, 2012

Heyman SN, Evans RG, Rosen S, Rosenberger C: Cellular adaptive changes in AKI: mitigating renal hypoxic injury. Nephrol Dial Transplant 27(5): 1721-1728, 2012

Schietke RE, Hackenbeck T, Tran M, Guenther R, Klanke B, Warnecke CL, Knaup KX, Shukla D, Rosenberger C, Koesters R, Bachmann S, Betz P, Schley G, Schoedel J, Willam C, Winkler T, Amann K, Eckardt KU, Maxwell P, Wiesner MS: Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cyts. PLoS ONE 7(1): e31034, 2012

Singh P, Blantz RC, Rosenberger C, Gabbai FB, Schoeb TR, Thomson SC: Aberrant tubuloglomerular feedback and HIF-1α confer resistance to ischemia after subtotal nephrectomy. J Am Soc Nephrol 23(3): 483-493, 2012
 

Publications 2011:

Liu Y, Krueger K, Hovsepian A, Tepel M, Thilo F: Calcium-dependent expression of transient receptor potential canonical type 3 channels in patients with chronic kidney disease. Arch Biochem Biophys. 514 (1-2): 44-49, 2011

Thilo F, Suess O, Liu Y, Tepel M: Decreased expression of transient receptor potential channels in cerebral vascular tissue from patients with hypertensive intracerebral hemorrhage. Clin Exp Hypertens. 33 (8): 533-537, 2011

Wong SL, Lau CW, Wong WT, Xu A, Au CL, Ng CF, Ng SS, Gollasch M, Yao X, Huang Y: Pivotal role of protein kinase Cdelta in angiotensin II-induced endothelial cyclooxygenase-2 expression: a link to vascular inflammation. Arterioscler Thromb Vasc Biol. 31(5):1169-76, 2011

Halmai R, Szijártó IA, Fehér E, Fésüs G, Molnár GA, Brasnyó P, Fülöp F, Gollasch M, Koller A, Wittmann I: Cigarette smoke elicits relaxation of renal arteries. Eur J Clin Invest. 41(2):195-202, 2011

Harteneck C, Gollasch M: Pharmacological modulation of diacylglycerol-sensitive TRPC3/6/7 channels. Curr Pharm Biotechnol. 12(1):35-41, 2011 (Review)

Ma L, Zhong J, Zhao Z, Luo Z, Ma S, Sun J, He H, Zhu T, Liu D, Zhu Z, Tepel M: Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis. Cardiovasc Res 92(3): 504-513, 2011 

Liu Y, Xu Y, Thilo F, Friis UG, Jensen BL, Scholze A, Zheng J, Tepel M: Erythropoietin increases expression and function of TRPC5 channels. Hypertension 58:317-324, 2011

da Costa Goncalves AC, Fontes MA, Klussmann E, Qadri F, Janke J, Gollasch M, Schleifenbaum J, Müller D, Jordan J, Tank J, Luft FC, Gross V: Spinophilin regulates central angiotensin II-mediated effect on blood pressure. J Mol Med (Berl). 89:1219-1229, 2011

Schildroth J, Rettig-Zimmermann J, Kalk P, Steege A, Schmidt S, Fähling M, Sendeski M, Paliege A, Lai EY, Relle K, Bachmann S, Persson PB, Hocher B, Patzak A: Endothelin type A and B receptors in the control of afferent and efferent arterioles in mice. Nephrol Dial Transplant 26(3):779-789, 2011

Sendeski MM: Pathophysiology of renal tissue damage by iodinated contrast media. Clinical and Experimental Pharmacology and Physiology (CEPP) 38: 292-299, 2011

Lüdemann L, Nafz B, Elsner F, Große-Siestrup C, Meissler M, Persson PB, Gutberlet M, Lengsfeld P, Voth M: Dependence of renal blood flow on renal artery stenosis measured using CT Angiography. Experimentelle Radiologie 183: 267-273, 2011

Benko E, Winkelmann A, Meier JC, Persson PB, Scholz H, Fähling M: Phorbol-ester mediated suppression of hASH1 synthesis: multiple ways to keep the level down. Frontiers in Molecular Neuroscience 4, Article 1: 1-11, 2011

Ladwig M, Flemming B, Seeliger E, Sargsyan L, Persson PB: Renal effects of bicarbonate vs. saline infusion for Iso- and Low-osmolar contrast media in rats. Investigative Radiology 46:672-677, 2011

Hoff U, Lukitsch I, Chaykovska L, Ladwig M, Arnold C, Manthati VL, Fuller TF, Schneider W, Gollasch M, Muller DN, Flemming B, Seeliger E, Luft FC, Falck JR, Dragun D, Schunck WH:  Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury. Kidney International 79:57-65, 2011

Paragas N, Qiu A, Zhang Q, Samstein B, Deng SX, Schmidt-Ott KM, Viltard M, Yu W, Forster CS, Gong G, Liu Y, Kulkarni R, Mori K, Kalandadze A, Ratner AJ, Devarajan P, Landry DW, D'Agati V, Lin CS, Barasch J: The Ngal reporter mouse detects the response of the kidney to injury in real time. Nature Medicine 17 (2): 216-222, 2011

Wuebken A, Schmidt-Ott KM: WNT/beta-catenin signaling in polycystic kidney disease. Kidney International 80 (2): 135-138, 2011

Singer E, Elger A, Elitok S, Kettritz R, Nickolas TL, Barasch J, Luft FC, Schmidt-Ott KM: Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes. Kidney International 80 (4): 405-414, 2011

Schmidt-Ott KM: Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury--where do we stand today? Nephrol Dial Transplant. 26 (3): 762-764, 2011

Heller, F, Frischmann S, Grünbaum M, Zidek W, Westhoff TH: Urinary calprotectin and the distinction between prerenal and instrinsic acute kidney injury. Clin J Am Soc Nephrol. 6:2347-2355, 2011

Kur E, Christa A, Veth KN, Gajera CR, Andrade-Navarro MA, Zhang J, Willer JR, Gregg RG, Abdelilah-Seyfried S, Bachmann S, Link BA, Hammes A, Willnow TE: Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development. Dev Dyn 240(6):1567-1577, 2011

Nomura N, Tajima M, Sugawara N, Morimoto T, Kondo Y, Ohno M, Uchida K, Mutig K, Bachmann S, Soleimani M, Ohta E, Ohta A, Sohara E, Okado T, Rai T, Jentsch TJ, Sasaki S, Uchida S: Generation and analyses of R8L barttin knockin mouse. Am J Physiol Renal Physiol  301:F297-F307, 2011

Heyman SN, Rosen S, Rosenberger C: A role for oxidative stress. Contrib Nephrol 174: 138-148, 2011

Heyman SN, Rosen S, Rosenberger C: Hypoxia-inducible factors and the prevention of acute organ injury. Crit Care 15(2): 209, 2011

Leh S, Hultström M, Rosenberger C, Iversen BM: Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats. Virchows Arch 459(1): 99-108, 2011

Heyman SN, Rosenberge C, Rosen S: Acute kidney injury: lessons from experimental models. Contrib Nephrol 169: 286-296, 2011

Dieringer MA, Renz W, Lindel T, Seifert F, Frauenrath T, von Knobelsdorff-Brenkenhoff F, Waiczies H, Hoffmann W, Rieger J, Pfeiffer H, Ittermann B, Schulz-Menger J, Niendorf T: Design and application of a four-channel transmit/receive surface coil for functional cardiac imaging at 7T. Journal of Magnetic Resonance Imaging 33 (3):736-741, 2011

Schulz V, Torres-Espallardo I, Renisch S, Hu ZB, Ojha N, Boernert P, Perkuhn M, Niendorf T, Schaefer WM, Brockmann H, Krohn T, Buhl A, Guenther RW, Mottaghy FM, Krombach GA: Automatic, three-segment, MR-based attenuation correction for whole-body PET/MR data. European Journal of Nuclear Medicine and Molecular Imaging 38 (1):138-152, 2011

Martin C, Frauenrath T, Oezerdem C, Renz W, Niendorf T: Development and evaluation of a small and mobile Magneto Alert Sensor (MALSE) to support safety requirements for magnetic resonance imaging. European Radiology 21:2187-2192, 2011

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